Supraphysiological doses of vitamin D changes brainwave activity patterns in rats

• Published in: Endocrine Connections Vol. 11; no. 3; pp. 1 - 10
• Main Authors: Lima, Gabriella Oliveira, Menezes da Silva, Alex Luiz, Azevedo, Julianne Elba Cunha, Nascimento, Chirlene Pinheiro, Vieira, Luana Rodrigues, Hamoy, Akira Otake, Oliveira Ferreira, Luan, Bahia, Verônica Regina Lobato Oliveira, Muto, Nilton Akio, Lopes, Dielly Catrina Favacho, Hamoy, Moisés
• Format: Journal Article
• Language: English
• Published: Bioscientifica Ltd 01.03.2022; Bioscientifica
• Subjects: brainwaves; electrocardiogram; hypercalcemia; vitamin d
• ISSN: 2049-3614; 2049-3614
• DOI: 10.1530/EC-21-0457

Low plasma levels of vitamin D causes bone mineral change that can precipitate osteopenia and osteoporosis, and could aggravate autoimmune diseases, hypertension and diabetes. The demand for vitamin D supplementation becomes necessary; however, the consumption of vitamin D is not without risks, which its toxicity could have potentially serious consequences related to hypervitaminosis D, such as hypercalcemia and cerebral alterations. Thus, the present study describes the electroencephalographic changes caused by supraphysiological doses of vitamin D in the brain electrical dynamics, and the electrocardiographic changes. After 4 days of treatment with vitamin D at dose of 25,000 IU/Kg, the serum calcium levels found was increased in comparison with control group. The ECoG analysis found a reduction in wave activity in the delta, theta, alpha and beta frequency bands. For ECG was observed changes with shortened QT follow-up, which could be related to serum calcium concentration. This study presented important evidence about the cerebral and cardiac alterations caused by high doses of vitamin D, indicating valuable parameters in the screening and decision-making process for diagnosing patients with symptoms suggestive of intoxication.