Roles for the VEZF1 transcription factor in erythroid and housekeeping gene expression

VEZF1 is a DNA-binding transcription factor that is highly conserved in vertebrates. Human VEZF1 has recently been found to interact with transcriptionally active gene promoters and erythroid specific enhancers. It is unclear how the broadly expressed VEZF1 interacts with enhancers in a cell type-sp...

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Bibliographic Details
Main Author Al-Hosni, Aliya M. R
Format Dissertation
LanguageEnglish
Published University of Glasgow 2017
Subjects
Q Science (General)
QH301 Biology
QH345 Biochemistry
QH426 Genetics
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Summary:VEZF1 is a DNA-binding transcription factor that is highly conserved in vertebrates. Human VEZF1 has recently been found to interact with transcriptionally active gene promoters and erythroid specific enhancers. It is unclear how the broadly expressed VEZF1 interacts with enhancers in a cell type-specific manner or what functions it plays at these elements. This work begins to address the cell-type specific roles of VEZF1 by creating loss of function models in a human erythroid cell line.
Bibliography:0000000463473139