Effect of cellular aging on fibroblastic phenotype and regulation by hyaluronan

Collectively, the data demonstrated that HA can serve as a signal integrator by facilitating TGF-beta11-mediated CD44-EGF-R-ERK interactions and ultimately regulate fibroblast phenotype. I propose a model to explain this novel mechanism and the functional consequence of age-dependent dysregulation....

Full description

Saved in:
Bibliographic Details
Main Author Simpson, Russell Michael Lloyd
Format Dissertation
LanguageEnglish
Published Cardiff University 2010
Online AccessGet full text

Cover

More Information
Summary:Collectively, the data demonstrated that HA can serve as a signal integrator by facilitating TGF-beta11-mediated CD44-EGF-R-ERK interactions and ultimately regulate fibroblast phenotype. I propose a model to explain this novel mechanism and the functional consequence of age-dependent dysregulation. This mechanism may have direct implications for modifying the wound healing response, particularly for developing therapeutic strategies to improve healing in the elderly.
Bibliography:0000000427510318