Uncharted biosynthetic potential of the ocean microbiome

• Published in: bioRxiv
• Main Authors: Paoli, Lucas, Ruscheweyh, Hans-Joachim, neris, Clarissa C, Satria Kautsar, Clayssen, Quentin, Salazar, Guillem, Milanese, Alessio, Gehrig, Daniel, Larralde, Martin, Carroll, Laura, Sanchez, Pablo, Zayed, Ahmed A, Cronin, Dylan R, Acinas, Silvia G, Bork, Peer, Bowler, Chris, Delmont, Tom O, Sullivan, Matthew B, Wincker, Patick, Zeller, Georg, Robinson, Serina L, Piel, Joern, Sunagawa, Shinichi
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 24.03.2021; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Bioactive compounds; Candidatus Eudoremicrobiaceae; Gene clusters; Genomes; Microbiology; Microbiomes; Natural products; Phylogeny; Transcription; meta-omics; natural products; Eudoremicrobium; Eudoremicrobiaceae; Amphithoemicrobium; genome-resolved microbiomics; biosynthetic potential; Autonoemicrobium; Ocean microbiome

Microbes are phylogenetically and metabolically diverse. Yet capturing this diversity, assigning functions to host organisms and exploring the biosynthetic potential in natural environments remains challenging. We reconstructed >25,000 draft genomes, including from >2,500 uncharacterized speci...