SARS-CoV-2 evolution and patient immunological history shape the breadth and potency of antibody-mediated immunity

• Published in: bioRxiv
• Main Authors: Manali, Maria, Bissett, Laura A, Amat, Julien, Logan, Nicola, Scott, Sam, Hughes, Ellen, Harvey, William, Orton, Richard, Thomson, Emma, Gunson, Rory, Viana, Mafalda, Willett, Brian, Pablo Ramiro Murcia
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 06.05.2022; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Antibodies; Antigenicity; Antigens; Herd immunity; Immunology; Microbiology; Severe acute respiratory syndrome coronavirus 2; Vaccination; SARS-CoV-2; immunological history; antibody-mediated immunity; virus neutralisation; virus evolution

Since the emergence of SARS-CoV-2, humans have been exposed to distinct SARS-CoV-2 antigens, either by infection with different variants, and/or vaccination. Population immunity is thus highly heterogeneous, but the impact of such heterogeneity on the effectiveness and breadth of the antibody-mediat...