Genomic Insights into the Population History and Adaptive Traits of Latin American Criollo Cattle

• Published in: bioRxiv
• Main Authors: Ward, James A, Ng'ang'a, Said I, Randhawa, Imtiaz A S, Mchugo, Gillian P, O'grady, John F, Flórez, Julio M, Browne, John A, Pérez O'brien, Ana M, Landaeta-Hernández, Antonio J, Garcia, José F, Sonstegard, Tad S, Frantz, Laurent A F, Salter-Townshend, Michael, Machugh, David E
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 06.01.2024; Cold Spring Harbor Laboratory
• Edition: 1.2
• Subjects: Adaptability; Bos taurus; Bos taurus indicus; Cattle; Climate change; Disease resistance; Gene flow; Genomics; Heat tolerance; Population structure; Temperature tolerance; Whole genome sequencing; microevolution; population genomics; cattle; selection; thermotolerance; Latin America
• ISSN: 2692-8205; 2692-8205
• DOI: 10.1101/2023.09.10.556512

Criollo cattle, descendants of animals brought by Iberian colonists to the Americas, have been subject to centuries of natural and human-mediated selection in novel tropical agroecological zones. Consequently, these breeds have evolved distinct characteristics such as resistance to disease and exceptional heat tolerance. In addition to European taurine (Bos taurus) ancestry, it has been proposed that gene flow from African taurine and Asian zebu (Bos indicus) cattle has shaped the ancestry of Criollo cattle. In this study, we analysed Criollo breeds from Colombia and Venezuela using whole genome sequencing data to examine population structure and admixture at very high resolution. We did not detect evidence of African taurine admixture in Criollo cattle; however, there was evidence of longstanding zebu ancestry in one breed (Hartón del Valle). In addition, we detected selection signatures associated with a myriad of adaptive traits, revealing genes linked to thermotolerance, reproduction, fertility, immunity, and distinct coat and skin coloration traits. This study underscores the remarkable adaptability of Criollo cattle and highlights the genetic richness and potential of these breeds in the face of climate change, habitat flux, and disease challenges. Further research is warranted to leverage these findings for more effective and sustainable cattle breeding programmes.Competing Interest StatementThe authors have declared no competing interest.Footnotes* We have redone some analyses with more appropriate comparator populations. We also rewritten the first part of the Introduction. In addition, some other small typographical errors/mistakes have been corrected.* https://www.ebi.ac.uk/ena/browser/view/PRJEB65887