Hereditary Breast Cancer: Clinical, Pathological and Molecular Characteristics

• Published in: Breast Cancer: Basic and Clinical Research Vol. 2014; no. 2014; pp. 145 - 155
• Main Authors: Larsen, Martin J., Thomassen, Mads, Gerdes, Anne-Marie, Kruse, Torben A.
• Format: Journal Article Book Review
• Language: English
• Published: London, England Libertas Academica 01.01.2014; SAGE Publishing; SAGE Publications; Sage Publications Ltd. (UK); Sage Publications Ltd
• Subjects: Breast cancer; Family; Genetic aspects; Genomics; Medical genetics; Review; BRCA1/2; microarray; hereditary breast cancer; review; clinical genetics; molecular profiling
• ISSN: 1178-2234; 1178-2234
• DOI: 10.4137/BCBCR.S18715

Pathogenic mutations in BRCA1 or BRCA2 are only detected in 25% of families with a strong history of breast cancer, though hereditary factors are expected to be involved in the remaining families with no recognized mutation. Molecular characterization is expected to provide new insight into the tumor biology to guide the search of new high-risk alleles and provide better classification of the growing number of BRCA1/2 variants of unknown significance (VUS). In this review, we provide an overview of hereditary breast cancer, its genetic background, and clinical implications, before focusing on the pathologically and molecular features associated with the disease. Recent transcriptome and genome profiling studies of tumor series from BRCA1/2 mutation carriers as well as familial npn-BRCA1/2 will be discussed. Special attention is paid to its association with molecular breast cancer subtypes as well as the latest advances in predicting BRCA1/2 involvement (BRCAness) using molecular signatures, for improved diagnostics and selection of patients sensitive to targeted therapeutics.