Node Detection Using High-Dimensional Fuzzy Parcellation Applied to the Insular Cortex

Several functional connectivity approaches require the definition of a set of regions of interest (ROIs) that act as network nodes. Different methods have been developed to define these nodes and to derive their functional and effective connections, most of which are rather complex. Here we aim to p...

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Published inJournal of neural transplantation & plasticity Vol. 2016; no. 2016; pp. 440 - 447-037
Main Authors Cauda, Franco, Geminiani, Giuliano, Duca, Sergio, Nani, Andrea, Costa, Tommaso, Diano, Matteo, Vercelli, Ugo, Vercelli, Alessandro
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Limiteds 01.01.2016
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Adult
Algorithms
Brain Mapping - methods
Cerebral cortex
Cerebral Cortex - physiology
Cluster Analysis
Clustering
Datasets
Female
Fuzzy algorithms
Fuzzy Logic
Fuzzy systems
Humans
Male
Nerve Net - physiology
Neurological research
Time series
Young Adult
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Summary:Several functional connectivity approaches require the definition of a set of regions of interest (ROIs) that act as network nodes. Different methods have been developed to define these nodes and to derive their functional and effective connections, most of which are rather complex. Here we aim to propose a relatively simple “one-step” border detection and ROI estimation procedure employing the fuzzy c-mean clustering algorithm. To test this procedure and to explore insular connectivity beyond the two/three-region model currently proposed in the literature, we parcellated the insular cortex of 20 healthy right-handed volunteers scanned in a resting state. By employing a high-dimensional functional connectivity-based clustering process, we confirmed the two patterns of connectivity previously described. This method revealed a complex pattern of functional connectivity where the two previously detected insular clusters are subdivided into several other networks, some of which are not commonly associated with the insular cortex, such as the default mode network and parts of the dorsal attentional network. Furthermore, the detection of nodes was reliable, as demonstrated by the confirmative analysis performed on a replication group of subjects.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Academic Editor: Yong Liu
ISSN:0792-8483
2090-5904
1687-5443
DOI:10.1155/2016/1938292