Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis

• Published in: Journal of neural transplantation & plasticity Vol. 2014; no. 2014; pp. 523 - 537
• Main Authors: Comeau, Samuel, Encinas, Juan M., Diaz-Aparicio, Irune, Beccari, Sol, Sierra, Amanda, Tremblay, Marie-Ève
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Limiteds 01.01.2014; Hindawi Publishing Corporation; John Wiley & Sons, Inc; Hindawi Limited; Wiley
• Subjects: Aging - immunology; Aging - physiology; Animals; Cytokines; Gene expression; Hippocampus - cytology; Hippocampus - growth & development; Hippocampus - physiology; Humans; Immunologic Surveillance - physiology; Inflammation; Inflammation - physiopathology; Memory; Microglia - physiology; Nervous system diseases; Neurodegenerative Diseases - pathology; Neurodegenerative Diseases - physiopathology; Neurogenesis; Neurogenesis - immunology; Neurogenesis - physiology; Nonsteroidal anti-inflammatory drugs; Phagocytosis - physiology; Physiological aspects; Physiology; Review; Stem cells; Stress, Psychological; Transgenic animals; Tumor necrosis factor-TNF

Microglia cells are the major orchestrator of the brain inflammatory response. As such, they are traditionally studied in various contexts of trauma, injury, and disease, where they are well-known for regulating a wide range of physiological processes by their release of proinflammatory cytokines, r...