Host restriction factors blocking retroviral replication

Retroviruses are highly successful intracellular parasites, and as such they are found in nearly all branches of life. Some are relatively benign, but many are highly pathogenic and can cause either acute or chronic diseases. Therefore, there is tremendous selective pressure on the host to prevent r...

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Bibliographic Details
Published inAnnual review of genetics Vol. 42; p. 143
Main Authors Wolf, Daniel, Goff, Stephen P
Format Journal Article
LanguageEnglish
Published United States 01.01.2008
Subjects
Animals
Antigens, CD - metabolism
Cytidine Deaminase - metabolism
GPI-Linked Proteins
Host-Pathogen Interactions - physiology
Humans
Membrane Glycoproteins - metabolism
Retroviridae - pathogenicity
Retroviridae - physiology
RNA, Viral - metabolism
RNA-Binding Proteins - metabolism
Virus Replication
Zinc Fingers
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Summary:Retroviruses are highly successful intracellular parasites, and as such they are found in nearly all branches of life. Some are relatively benign, but many are highly pathogenic and can cause either acute or chronic diseases. Therefore, there is tremendous selective pressure on the host to prevent retroviral replication, and for this reason cells have evolved a variety of restriction factors that act to inhibit or block the viruses. This review is a survey of the best-characterized restriction factors capable of inhibiting retroviral replication and aims to highlight the diversity of strategies used for this task.
ISSN:0066-4197
DOI:10.1146/annurev.genet.42.110807.091704