Electrochemical Nickel Catalysis for Sp2‑Sp3 Cross-Electrophile Coupling Reactions of Unactivated Alkyl Halides

A constant-current electrochemical method for reducing catalytic nickel complexes in sp2-sp3 cross-electrophile coupling reactions has been developed. The electrochemical reduction provides reliable nickel catalyst activation and turnover and offers a tunable parameter for reaction optimization, in...

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Bibliographic Details
Published inOrganic letters Vol. 19; no. 14; pp. 3755 - 3758
Main Authors Perkins, Robert J, Pedro, Dylan J, Hansen, Eric C
Format Journal Article
LanguageEnglish
Published American Chemical Society 21.07.2017
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Summary:A constant-current electrochemical method for reducing catalytic nickel complexes in sp2-sp3 cross-electrophile coupling reactions has been developed. The electrochemical reduction provides reliable nickel catalyst activation and turnover and offers a tunable parameter for reaction optimization, in contrast to more standard activated metal powder reductants. The electrochemical reactions give yields (i.e., 51–86%) and selectivities as high or superior to those using metal powder reductants and provide access to a wider substrate scope.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b01598