The Alliance of Mesenchymal Stem Cells, Bone, and Diabetes

Bone fragility has emerged as a new complication of diabetes. Several mechanisms in diabetes may influence bone homeostasis by impairing the action between osteoblasts, osteoclasts, and osteocytes and/or changing the structural properties of the bone tissue. Some of these mechanisms can potentially...

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Bibliographic Details
Published inInternational Journal of Endocrinology Vol. 2014; no. 2014; pp. 509 - 534-157
Main Authors Pozzilli, Paolo, Briganti, Silvia I., Paladini, Angela, Strollo, Rocky, Napoli, Nicola, Epstein, Sol
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Limiteds 01.01.2014
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Adipocytes
Bone diseases
Bone marrow
Complications and side effects
Diabetes
Endocrinology
Fractures
Growth factors
Homeostasis
Hormones
Kinases
Ligands
Mutation
Obesity
Proteins
Review
Risk factors
Stem cells
Transcription factors
Tumor necrosis factor-TNF
Type 2 diabetes
Weight control
United States
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Summary:Bone fragility has emerged as a new complication of diabetes. Several mechanisms in diabetes may influence bone homeostasis by impairing the action between osteoblasts, osteoclasts, and osteocytes and/or changing the structural properties of the bone tissue. Some of these mechanisms can potentially alter the fate of mesenchymal stem cells, the initial precursor of the osteoblast. In this review, we describe the main factors that impair bone health in diabetic patients and their clinical impact.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Academic Editor: Debra Waters
ISSN:1687-8337
1687-8345
DOI:10.1155/2014/690783