Serum Osteoprotegerin Is a Potential Biomarker of Insulin Resistance in Chinese Postmenopausal Women with Prediabetes and Type 2 Diabetes

• Published in: International Journal of Endocrinology Vol. 2017; no. 2017; pp. 1 - 8
• Main Authors: Liu, Jia, Wei, Meilin, Yang, Min, Duan, Peng, Tu, Ping
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Limiteds 01.01.2017; Hindawi Publishing Corporation; Hindawi; John Wiley & Sons, Inc; Wiley
• Subjects: Age; Analysis; Atherosclerosis; Biomarkers; Body fat; Body mass index; Calcification; Cardiovascular disease; Cholesterol; Complications and side effects; Creatinine; Development and progression; Diabetes; Diagnosis; Endocrinology; Genetic aspects; Glucose; Homeostasis; Insulin resistance; Metabolism; Physiological aspects; Plasma; Postmenopausal women; Prediabetic state; Risk factors; Statistical analysis; Studies; Type 2 diabetes; Variables; Womens health; China; United States > US; Japan
• ISSN: 1687-8337; 1687-8345
• DOI: 10.1155/2017/8724869

The aim of this study is to investigate the circulating OPG levels in postmenopausal women with diabetes and prediabetes and explore the relationships between serum OPG and insulin resistance. A total of 271 unrelated Chinese postmenopausal women were recruited in this study. The subjects were divided into type 2 diabetes mellitus (T2DM) group (n=93), impaired glucose regulation (IGR) (n=90), and normal glucose regulation group (NGR) (n=88), according to different glucose regulation categories. Serum OPG levels were measured by enzyme-linked immunosorbent assay. The serum OPG concentration in NGR group, 151.00 ± 45.72 pg/mL, was significantly lower than that in IGR group (169.28 ± 64.91 pg/mL) (p=0.031) and T2DM group (183.20 ± 56.53 pg/mL) (p<0.01), respectively. In multiple linear regression analysis, HOMA-IR, age, 2hPG, AST, ALP, and eGFR were found to be independent predictors of OPG. Increased serum OPG levels (OR = 1.009, p=0.006) may be a risk factor for insulin resistance. The present study suggests that OPG might be implicated in the pathogenesis of diabetes and is a potential biomarker of insulin resistance in subjects with diabetes and prediabetes.