Association between Lower Normal Free Thyroxine Concentrations and Obesity Phenotype in Healthy Euthyroid Subjects

We investigated whether thyroid function could identify obesity phenotype in euthyroid subjects. A cross-sectional analysis was performed among nondiabetic, euthyroid subjects. We stratified subjects into four groups by BMI and insulin resistance (IR). Of 6241 subjects, 33.8% were overweight or obes...

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Published inInternational Journal of Endocrinology Vol. 2014; no. 2014; pp. 30 - 37-003
Main Authors Moon, Sung Dae, Kim, Eun Sook, Mo, Eun young, Shin, Jeong Ah, Han, Je Ho
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Limiteds 01.01.2014
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Wiley
Subjects
Analysis
Blood pressure
Body mass index
Cholesterol
Complications and side effects
Endocrinology
Genetic aspects
Glucose
Goiter
Hypertension
Immunoassay
Insulin resistance
Metabolism
Mortality
Obesity
Physiological aspects
Thyroid gland
Thyroxine
South Korea
Japan
Germany
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Summary:We investigated whether thyroid function could identify obesity phenotype in euthyroid subjects. A cross-sectional analysis was performed among nondiabetic, euthyroid subjects. We stratified subjects into four groups by BMI and insulin resistance (IR). Of 6241 subjects, 33.8% were overweight or obese (OW/OB) and 66.2% were normal weight (NW). Free thyroxine (FT4) levels were negatively associated with body mass index, waist circumference, triglyceride, c-reactive protein, and HOMA-IR and positively with high-density lipoprotein cholesterol in both genders. In multivariate regression analysis, FT4 level, a continuous measurement, was negatively correlated with HOMA-IR (β=-0.155, P<0.001 in men; β=-0.175, P<0.001 in women). After adjustment for age, sex, metabolic, and life style factors, subjects in the lowest FT4 quartile had an odds ratio (OR) for IR of 1.99 (95% confidence interval 1.61–2.46), as compared to those in the highest quartile. The association between low FT4 and IR remained significant in both NW and OW/OB subgroups. In conclusion, low normal FT4 levels were independently related to IR in NW and OW/OB euthyroid subjects. Further studies are needed to investigate the mechanisms by which low FT4 levels are linked to high IR in euthyroid ranges.
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Academic Editor: Amelie Bonnefond
ISSN:1687-8337
1687-8345
DOI:10.1155/2014/104318