Is Bisphosphonate-Related Osteonecrosis of the Jaw an Infection? A Histological and Microbiological Ten-Year Summary

The role of infection in the etiology of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is poorly understood. Large-scale epidemiological descriptions of the histology and microbiology of BRONJ are not found in the literature. Herein, we present a systematic review of BRONJ histology and mi...

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Published inInternational Journal of Dentistry Vol. 2014; no. 2014; pp. 261 - 267
Main Authors Hinson, A. M., Smith, C. W., Siegel, E. R., Stack, B. C.
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Limiteds 01.01.2014
Hindawi Puplishing Corporation
Hindawi Publishing Corporation
Hindawi Limited
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Review
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Summary:The role of infection in the etiology of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is poorly understood. Large-scale epidemiological descriptions of the histology and microbiology of BRONJ are not found in the literature. Herein, we present a systematic review of BRONJ histology and microbiology (including demographics, immunocompromised associations, clinical signs and symptoms, disease severity, antibiotic and surgical treatments, and recovery status) validating that infection should still be considered a prime component in the multifactorial disease.
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Academic Editor: Giuliano Ascani
ISSN:1687-8728
1687-8736
DOI:10.1155/2014/452737