Heart Rate Variability in Children with Tricyclic Antidepressant Intoxication

• Published in: Cardiology Research and Practice Vol. 2013; no. 2013; pp. 59 - 65
• Main Authors: Ucar, Birsen, Yargic, Zeynel Abidin, Eren, Makbule, Kosger, Pelin, Tutuncu-Toker, Rabia, Sahin, Sabiha, Dinleyici, Ener Cagri, Kilic, Zubeyir
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Limiteds 01.01.2013; Hindawi Puplishing Corporation; Hindawi Publishing Corporation; Hindawi Limited; Wiley
• Subjects: Antidepressants, Tricyclic; Blood pressure; Cardiac arrhythmia; Cardiovascular research; Children; Clinical Study; Complications and side effects; Drunkenness (Criminal law); Electrocardiography; Enzymes; Fainting; Health aspects; Heart beat; Heart rate; Immunoassay; Laboratories; Nervous system; Patients; Physiological aspects; Poisoning; Poisons; Sinuses; Statistical analysis; Values
• ISSN: 2090-0597; 2090-8016; 2090-0597
• DOI: 10.1155/2013/196506

The aim of this study was to evaluate HRV in children requiring intensive care unit stays due to TCA poisoning between March 2009 and July 2010. In the time-domain nonspectral evaluation, the SDNN (P<0.001), SDNNi (P<0.05), RMSDD (P<0.01), and pNN50 (P<0.01) were found to be significantly lower in the TCA intoxication group. The spectral analysis of the data recorded during the first 5 minutes after intensive care unit admission showed that the values of the nLF (P<0.05) and the LF/HF ratio (P=0.001) were significantly higher in the TCA intoxication group, while the nHF (P=0.001) values were significantly lower. The frequency-domain spectral analysis of the data recorded during the last 5 minutes showed a lower nHF (P=0.001) in the TCA intoxication group than in the controls, and the LF/HF ratio was significantly higher (P<0.05) in the intoxication group. The LF/HF ratio was higher in the seven children with seizures (P<0.001). These findings provided us with a starting point for the value of HRV analysis in determining the risk of arrhythmia and convulsion in TCA poisoning patients. HRV can be used as a noninvasive testing method in determining the treatment and prognosis of TCA poisoning patients.