Spinal Osteosarcoma

Although osteosarcoma represents the second most common primary bone tumor, spinal involvement is rare, accounting for 3%–5% of all osteosarcomas. The most frequent symptom of osteosarcoma is pain, which appears in almost all patients, whereas more than 70% exhibit neurologic deficit. At a molecular...

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Published inClinical Medicine Insights. Oncology Vol. 2013; no. 7; pp. 199 - 208
Main Authors Katonis, P., Datsis, G., Karantanas, A., Kampouroglou, A., Lianoudakis, S., Licoudis, S., Papoutsopoulou, E., Alpantaki, K.
Format Journal Article Book Review
LanguageEnglish
Published London, England Libertas Academica 18.08.2013
SAGE Publishing
SAGE Publications
Sage Publications Ltd. (UK)
Sage Publications Ltd
Subjects
Adjuvant treatment
Cancer
Development and progression
Genetic aspects
Osteosarcoma
Prognosis
Review
Tumors
spine
imaging/diagnosis
primary tumors
osteosarcoma
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Summary:Although osteosarcoma represents the second most common primary bone tumor, spinal involvement is rare, accounting for 3%–5% of all osteosarcomas. The most frequent symptom of osteosarcoma is pain, which appears in almost all patients, whereas more than 70% exhibit neurologic deficit. At a molecular level, it is a tumor of great genetic complexity and several genetic disorders have been associated with its appearance. Early diagnosis and careful surgical staging are the most important factors in accomplishing sufficient management. Even though overall prognosis remains poor, en-block tumor removal combined with adjuvant radiotherapy and chemotherapy is currently the treatment of choice. This paper outlines histopathological classification, epidemiology, diagnostic procedures, and current concepts of management of spinal osteosarcoma.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1179-5549
1179-5549
DOI:10.4137/CMO.S10099