Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials

Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with complex etiology and pathophysiology, which remains poorly understood. It affects about 5–10% of women of reproductive age who typically suffer from obesity, hyperandrogenism, ovarian dysfunction, and menstrual irregularity. Indee...

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Published inInternational Journal of Endocrinology Vol. 2016; no. 2016; pp. 162 - 173-017
Main Authors Prapas, Nikos, Kamenov, Zdravko A., Nestler, John E., Unfer, Vittorio, Facchinetti, Fabio
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Limiteds 01.01.2016
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Age
Amenorrhea
Analysis
Blood pressure
Body mass index
Cholesterol
Clinical trials
Complications and side effects
Congenital diseases
Diabetes
Dosage and administration
Drug therapy
Endocrinology
Glucose
Health aspects
Hyperplasia
In vitro fertilization
Inositol
Insulin resistance
Interlibrary loans
Lipoproteins
Metabolism
Pathogenesis
Polycystic ovary syndrome
Product development
Quality
Review
Stein-Leventhal syndrome
Systematic review
Thyroid gland
Triglycerides
Womens health
Bulgaria
Italy
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Summary:Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with complex etiology and pathophysiology, which remains poorly understood. It affects about 5–10% of women of reproductive age who typically suffer from obesity, hyperandrogenism, ovarian dysfunction, and menstrual irregularity. Indeed, PCOS is the most common cause of anovulatory infertility in industrialized nations, and it is associated with insulin resistance, type 2 diabetes mellitus, and increased cardiovascular risk. Although insulin resistance is not included as a criterion for diagnosis, it is a critical pathological condition of PCOS. The purpose of this systematic review is the analysis of recent randomized clinical trials of inositol(s) in PCOS, in particular myo- and D-chiro-inositol, in order to better elucidate their physiological involvement in PCOS and potential therapeutic use, alone and in conjunction with assisted reproductive technologies, in the clinical treatment of women with PCOS.
Bibliography:ObjectType-Article-2
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Academic Editor: Michael Horowitz
ISSN:1687-8337
1687-8345
DOI:10.1155/2016/1849162