Methylation Operation Wizard (MeOW): Identification of differentially methylated regions in long-read sequencing data

Long-read sequencing (LRS) is able to simultaneously capture information about both DNA sequence and modifications, such as CpG methylation in a single sequencing experiment. Here we present Methylation Operation Wizard (MeOW), a program to identify and prioritize differentially methylated regions (...

Full description

Saved in:
Bibliographic Details
Main Authors Zalusky, Miranda PG, Miller, Danny E
Format Journal Article
LanguageEnglish
Published 26.02.2024
Subjects
Quantitative Biology - Genomics
Quantitative Biology - Quantitative Methods
Online AccessGet full text

Cover

More Information
Summary:Long-read sequencing (LRS) is able to simultaneously capture information about both DNA sequence and modifications, such as CpG methylation in a single sequencing experiment. Here we present Methylation Operation Wizard (MeOW), a program to identify and prioritize differentially methylated regions (DMRs) genome-wide using LRS data. MeOW can be run using either a file containing counts of per-nucleotide methylated CpG sites or with a bam file containing modified base tags.
DOI:10.48550/arxiv.2402.17182