Metastasizing Pleomorphic Adenoma: A Fascinating Enigma

Among salivary gland neoplasms, metastasizing pleomorphic adenoma (MPA) constitutes an extremely rare group of tumors. The present paper reports a case of pleomorphic adenoma (PA) in submandibular gland that, after more than 30 years of initial treatment, recurred and metastasized to ipsilateral nec...

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Bibliographic Details
Published inCase Reports in Medicine Vol. 2012; no. 2012; pp. 1 - 5-013
Main Authors Sánchez-Santiago, María, Morales, Gary, Santini, Héctor, Arroyo, Axel, Santaliz-Ruiz, Luis E. IV
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Limiteds 01.01.2012
Hindawi Puplishing Corporation
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Care and treatment
Case Report
Diagnosis
Metastasis
Patient outcomes
Salivary gland tumors
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Summary:Among salivary gland neoplasms, metastasizing pleomorphic adenoma (MPA) constitutes an extremely rare group of tumors. The present paper reports a case of pleomorphic adenoma (PA) in submandibular gland that, after more than 30 years of initial treatment, recurred and metastasized to ipsilateral neck lymph nodes and parotid gland. In an attempt to elucidate the malignant behavior of metastasizing pleomorphic adenoma, we performed Ki-67, p53, p16, and bcl-2 immunohistochemistry staining of our case sample. Many immunohistochemistry staining studies have been done on malignant salivary gland tumors. However, to the best of our knowledge no immunohistochemistry staining of the aforementioned markers has been previously performed on metastasizing pleomorphic adenoma.
Bibliography:ObjectType-Article-1
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Academic Editor: David W. Eisele
ISSN:1687-9627
1687-9635
DOI:10.1155/2012/148103