Mechanism by Which Mutations at His274 Alter Sensitivity of Influenza A Virus N1 Neuraminidase to Oseltamivir Carboxylate and Zanamivir

• Published in: Antimicrobial Agents and Chemotherapy Vol. 46; no. 12; pp. 3809 - 3816
• Main Authors: WANG, Michael Z, TAI, Chun Y, MENDEL, Dirk B
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.12.2002
• Subjects: Acetamides; Acetamides - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Antiviral Agents - pharmacology; Biological and medical sciences; Guanidines; Influenza A virus; Influenza A virus - drug effects; Influenza A virus - enzymology; Influenza A virus - genetics; Medical sciences; Mutation; Neuraminidase; Neuraminidase - antagonists & inhibitors; Oseltamivir; Pharmacology. Drug treatments; Pyrans; Sialic Acids; Sialic Acids - pharmacology; Structure-Activity Relationship; Zanamivir; Drug susceptibility test; Enzyme; Enzyme inhibitor; Orthomyxoviridae; Zanamivir; Virus; Resistance; Oseltamivir; Histidine; Influenzavirus A; Glycosidases; Exo-α-sialidase; Hydrolases; Antiviral; Mutation; O-Glycosidases
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.46.12.3809-3816.2002

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