DNA Mismatch Repair in Eukaryotes and Bacteria

DNA mismatch repair (MMR) corrects mismatched base pairs mainly caused by DNA replication errors. The fundamental mechanisms and proteins involved in the early reactions of MMR are highly conserved in almost all organisms ranging from bacteria to human. The significance of this repair system is also...

Full description

Saved in:
Bibliographic Details
Published inJournal of Nucleic Acids Vol. 2010; no. 2010; pp. 193 - 208
Main Author Fukui, Kenji
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Limiteds 01.01.2010
Hindawi Puplishing Corporation
SAGE-Hindawi Access to Research
John Wiley & Sons, Inc
Wiley
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:DNA mismatch repair (MMR) corrects mismatched base pairs mainly caused by DNA replication errors. The fundamental mechanisms and proteins involved in the early reactions of MMR are highly conserved in almost all organisms ranging from bacteria to human. The significance of this repair system is also indicated by the fact that defects in MMR cause human hereditary nonpolyposis colon cancers as well as sporadic tumors. To date, 2 types of MMRs are known: the human type and Escherichia coli type. The basic features of the former system are expected to be universal among the vast majority of organisms including most bacteria. Here, I review the molecular mechanisms of eukaryotic and bacterial MMR, emphasizing on the similarities between them.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Academic Editor: Shigenori Iwai
ISSN:2090-021X
2090-0201
2090-021X
DOI:10.4061/2010/260512