Brain Histamine N-Methyltransferase As a Possible Target of Treatment for Methamphetamine Overdose

Stereotypical behaviors induced by methamphetamine (METH) overdose are one of the overt symptoms of METH abuse, which can be easily assessed in animal models. Currently, there is no successful treatment for METH overdose. There is increasing evidence that elevated levels of brain histamine can atten...

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Bibliographic Details
Published inDrug Target Insights Vol. 2016; no. 2016; pp. 1 - 7
Main Authors Kitanaka, Junichi, Kitanaka, Nobue, Hall, F. Scott, Uhl, George R., Takemura, Motohiko
Format Journal Article Book Review
LanguageEnglish
Published London, England Libertas Academica 01.01.2016
SAGE Publishing
SAGE Publications
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Subjects
Review
overdose
histamine N-methyltransferase
Stereotyped behavior
brain histaminergic system
methamphetamine
metoprine
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Summary:Stereotypical behaviors induced by methamphetamine (METH) overdose are one of the overt symptoms of METH abuse, which can be easily assessed in animal models. Currently, there is no successful treatment for METH overdose. There is increasing evidence that elevated levels of brain histamine can attenuate METH-induced behavioral abnormalities, which might therefore constitute a novel therapeutic treatment for METH abuse and METH overdose. In mammals, histamine N-methyltransferase (HMT) is the sole enzyme responsible for degrading histamine in the brain. Metoprine, one of the most potent HMT inhibitors, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT. Consequently, this compound can be a candidate for a prototype of drugs for the treatment of METH overdose.
Bibliography:ObjectType-Article-2
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ISSN:1177-3928
1177-3928
DOI:10.4137/DTI.S38342