Progenetix: 12 years of oncogenomic data curation
DNA copy number aberrations (CNAs) can be found in the majority of cancer genomes, and are crucial for understanding the potential mechanisms underlying tumor initiation and progression. Since the first release in 2001, the Progenetix project (http://www.progenetix.org) has provided a reference reso...
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Main Authors | , , , , , |
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Format | Journal Article |
Language | English |
Published |
12.11.2013
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Subjects | |
Online Access | Get full text |
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Summary: | DNA copy number aberrations (CNAs) can be found in the majority of cancer
genomes, and are crucial for understanding the potential mechanisms underlying
tumor initiation and progression. Since the first release in 2001, the
Progenetix project (http://www.progenetix.org) has provided a reference
resource dedicated to provide the most comprehensive collection of genome-wide
CNA profiles. Reflecting the application of comparative genomic hybridization
(CGH) techniques to tens of thousands of cancer genomes, over the past 12 years
our data curation efforts have resulted in a more than 60-fold increase in the
number of cancer samples presented through Progenetix. In addition, new data
exploration tools and visualization options have been added. In particular, the
gene specific CNA frequency analysis should facilitate the assignment of cancer
genes to related cancer types. Additionally, the new user file processing
interface allows users to take advantage of the online tools, including various
data representation options for proprietary data pre-publication. In this
update article, we report recent improvements of the database in terms of
content, user interface and online tools. |
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DOI: | 10.48550/arxiv.1311.2757 |