Anti-CCP Antibodies Are Not Associated with Familial Mediterranean Fever in Childhood

• Published in: International Journal of Rheumatology Vol. 2013; no. 2013; pp. 89 - 92
• Main Authors: Onur, Hatice, Aral, Hale, Arica, Vefik, Bercem, Gamze, Usta, Murat, Kasapçopur, Özgür
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Limiteds 01.01.2013; Hindawi Puplishing Corporation; Hindawi Publishing Corporation; John Wiley & Sons, Inc; Hindawi Limited; Wiley
• Subjects: Analysis; C-reactive protein; Care and treatment; Clinical Study; Colchicine; Diagnosis; Familial Mediterranean fever; Genetic aspects; Health aspects
• ISSN: 1687-9260; 1687-9279
• DOI: 10.1155/2013/498581

Objective. Anticyclic citrullinated peptide antibodies (anti-CCP) testing is useful in the diagnosis of rheumatoid arthritis (RA) with high specificity. Arthritis is a very common clinical manifestation in children with familial Mediterranean fever (FMF). The aim of the study was to show the presence of anti-CCP antibodies in child individuals diagnosed with FMF. Material and Methods. The study groups comprised one hundred and twenty-six patients (126) diagnosed with FMF (female/male (n): 66/60) and 50 healthy controls (female/male (n): 25/25). Clinical and laboratory assessments of the FMF patients were performed during attack-free periods. Erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP), fibrinogen, and anti-CCP antibody levels were measured. Results. Anti-CCP was negative in healthy controls and also in all FMF patients. There was not a significant difference in anti-CCP between the patient and the control groups. Our study has shown that anti-CCP was correlated moderately with age (rs=0.271; P=0.0020), duration of illness (rs=0.331; P<0.0001), and colchicine therapy (rs=0.259; P=0.004). Conclusion. Our data show that anti-CCP antibodies are not associated with FMF. Anti-CCP does not have a priority for identifying FMF arthritis from the other inflammatory arthritis.