Increased NHC Cells in the Peritoneal Cavity of Plasmacytoma Susceptible BALB/c Mouse

• Published in: Mediators of Inflammation Vol. 2015; no. 2015; pp. 235 - 243-121
• Main Authors: Berenice Sánchez-González, Francisco Javier García-Vázquez, José Eduardo Farfán-Morales, Luis Antonio Jiménez-Zamudio
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Limiteds 01.01.2015; Hindawi Publishing Corporation; Hindawi Limited; Wiley
• Subjects: Animals; B cells; Cloning; Cytokines; Cytokines - metabolism; Disease Models, Animal; Female; Inflammation; Laboratory animals; Lymphocytes; Lymphocytes - cytology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Multiple myeloma; Oils; Peritoneal Cavity; Physiological aspects; Plasmacytoma; Plasmacytoma - metabolism; Rodents; Studies; T-Lymphocytes, Helper-Inducer - cytology; T-Lymphocytes, Regulatory - cytology; Terpenes - chemistry; Th17 Cells - metabolism
• ISSN: 0962-9351; 1466-1861
• DOI: 10.1155/2015/313140

BALB/c strain mice are unique in that they develop murine plasmacytoma (MPC) as a consequence of the inflammation induced by pristane oil injection in the peritoneal cavity. In this work the Treg, Th17, B1, B2, and NHC lymphocyte populations from the peritoneal environment of BALB/c, the susceptible strain, and C57BL/6 mice, which do not develop MPC after oil treatment, were studied. Both oil-treated strains showed decreased levels of Th17 lymphocytes, no significant variation in Treg lymphocytes, and a drastic decrease of all B lymphocyte populations. However, only oil-induced BALB/c showed increased levels of natural helper cells (NHC) which could be important in the myeloma induction.