Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach

• Published in: International Journal of Vascular Medicine Vol. 2010; no. 2010; pp. 48 - 56
• Main Authors: Lobbes, M. B. I., Kooi, M. E., Lutgens, E., Ruiters, A. W., Passos, Valéria Lima, Braat, S. H. J. G., Rousch, M., Ten Cate, H., van Engelshoven, J. M. A., Daemen, M. J. A. P., Heeneman, S.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Limiteds 01.01.2010; Hindawi Puplishing Corporation; John Wiley & Sons, Inc; Hindawi Publishing Corporation; Wiley
• Subjects: Angina pectoris; Biological markers; Clinical Study; Diagnosis; Heart attack; Leukocytes; Peroxidase; Physiological aspects; Netherlands
• ISSN: 2090-2824; 2090-2832
• DOI: 10.1155/2010/726207

We evaluated leukocyte counts and levels of CRP, fibrinogen, MPO, and PAPP-A in patients with stable and unstable angina pectoris, acute myocardial infarction, and healthy controls. All biomarkers were analyzed again after 6 months. Leukocyte counts and concentrations of fibrinogen, CRP, MPO, and PAPP-A were significantly increased in patients with acute myocardial infarction. Leukocyte counts and concentrations of MPO were significantly increased in patients with unstable angina pectoris compared with controls. After 6 months, leukocyte counts and MPO concentrations were still increased in patients with acute myocardial infarction when compared to controls. Discriminant analysis showed that leukocyte counts, MPO, and PAPP-A concentrations classified study group designation for acute coronary events correctly in 83% of the cases. In conclusion, combined assessment of leukocyte counts, MPO, and PAPP-A was able to correctly classify acute coronary events, suggesting that this could be a promising panel for a multibiomarker approach to assess cardiovascular risk.