Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-D-glucan synthase inhibitors

• Published in: Antimicrobial Agents and Chemotherapy Vol. 41; no. 11; pp. 2471 - 2479
• Main Authors: DOUGLAS, C. M, D'IPPOLITO, J. A, MITCHELL, A, KURTZ, M. B, SHEI, G. J, MEINZ, M, ONISHI, J, MARRINAN, J. A, LI, W, ABRUZZO, G. K, FLATTERY, A, BARTIZAL, K
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.11.1997
• Subjects: Amino Acid Sequence; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal Agents; Base Sequence; Biological and medical sciences; Candida albicans; Candida albicans - genetics; Drug Resistance, Microbial - genetics; Echinocandins; Enzyme Inhibitors; Enzyme Inhibitors - pharmacology; Fungal Proteins; Fungal Proteins - drug effects; Fungal Proteins - genetics; Genotype; Glucosyltransferases; Glucosyltransferases - antagonists & inhibitors; Medical sciences; Membrane Proteins; Membrane Proteins - drug effects; Membrane Proteins - genetics; Mice; Molecular Sequence Data; Pharmacology. Drug treatments; Phenotype; Saccharomyces cerevisiae Proteins; Schizosaccharomyces pombe Proteins; Candida albicans; Yeast; Virulence; Glycosyltransferases; Fungi; Antifungal agent; Ascomycetes; Fungi Imperfecti; Thallophyta; Genetic transformation; Nucleotide sequence; Enzyme; Transferases; Rodentia; Enzyme inhibitor; 1,3-β-Glucan synthase; In vitro; Plasmid; Resistance; In vivo; Vertebrata; Mammalia; Mouse; Animal; Microorganism culture; Hexosyltransferases; Mutation; Saccharomyces cerevisiae
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.41.11.2471

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