Biosynthetic Pathway for Mannopeptimycins, Lipoglycopeptide Antibiotics Active against Drug-Resistant Gram-Positive Pathogens

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Published inAntimicrobial Agents and Chemotherapy Vol. 50; no. 6; pp. 2167 - 2177
Main Authors MAGARVEY, Nathan A, HALTLI, Brad, MIN HE, GREENSTEIN, Michael, HUCUL, John A
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.06.2006
Subjects
Anti-Bacterial Agents
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Biosynthesis
Chemistry
Chemistry; Biosynthesis
Cloning, Molecular
Cosmids
Drug Resistance, Bacterial
Genes, Bacterial
Glycopeptides
Glycopeptides - biosynthesis
Glycopeptides - chemistry
Glycopeptides - genetics
Glycopeptides - pharmacology
Gram-Positive Bacteria
Gram-Positive Bacteria - drug effects
Gram-Positive Bacteria - isolation & purification
Medical sciences
Models, Biological
Multigene Family - genetics
Oligosaccharides - biosynthesis
Oligosaccharides - genetics
Oligosaccharides - metabolism
Open Reading Frames
Pharmacology. Drug treatments
Protein Structure, Tertiary
Streptomyces - enzymology
Streptomyces - genetics
Streptomyces - metabolism
Streptomyces hygroscopicus
Substrate Specificity
Antibiotic
Treatment resistance
Glycopeptide
Gram positive bacteria
Pathogenic
Mannopeptimycine derivatives
Antibacterial agent
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
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Corresponding author. Mailing address: Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965. Phone: (845) 602-2449. Fax: (845) 602-5687. E-mail: huculj@wyeth.com.
Present address: Harvard University, Harvard Medical School, Department of Biological Chemistry and Molecular Pharmacology, 240 Longwood Avenue, Armenise Building, Boston, MA 02115.
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.01545-05