From Melanocyte to Metastatic Malignant Melanoma

Malignant melanoma is one of the most aggressive malignancies in human and is responsible for almost 60% of lethal skin tumors. Its incidence has been increasing in white population in the past two decades. There is a complex interaction of environmental (exogenous) and endogenous, including genetic...

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Bibliographic Details
Published inDermatology Research and Practice Vol. 2010; no. 1
Main Authors Bandarchi, Bizhan, Ma, Linglei, Navab, Roya, Seth, Arun, Rasty, Golnar
Format Journal Article
LanguageEnglish
Published Egypt Hindawi Limiteds 01.01.2010
Hindawi Publishing Corporation
Hindawi Limited
Wiley
Subjects
Care and treatment
Diagnosis
Melanoma
Review
Skin cancer
Canada
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Summary:Malignant melanoma is one of the most aggressive malignancies in human and is responsible for almost 60% of lethal skin tumors. Its incidence has been increasing in white population in the past two decades. There is a complex interaction of environmental (exogenous) and endogenous, including genetic, risk factors in developing malignant melanoma. 8–12% of familial melanomas occur in a familial setting related to mutation of the CDKN2A gene that encodes p16. The aim of this is to briefly review the microanatomy and physiology of the melanocytes, epidemiology, risk factors, clinical presentation, historical classification and histopathology and, more in details, the most recent discoveries in biology and genetics of malignant melanoma. At the end, the final version of 2009 AJCC malignant melanoma staging and classification is presented.
Bibliography:Academic Editor: Prashiela Manga
ISSN:1687-6105
1687-6113
DOI:10.1155/2010/583748