Changes in Serum Levels of Bone Morphogenic Protein 4 and Inflammatory Cytokines after Bariatric Surgery in Severely Obese Korean Patients with Type 2 Diabetes

Serum bone morphogenic protein- (BMP-) 4 levels are associated with human adiposity. The aim of this study was to investigate changes in serum levels of BMP-4 and inflammatory cytokines after Roux-en-Y gastric bypass (RYGB). Fifty-seven patients with type 2 diabetes underwent RYGB. Serum levels of B...

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Published inInternational Journal of Endocrinology Vol. 2013; no. 2013; pp. 382 - 386-143
Main Authors Kim, Mee Kyoung, Jang, Eun-Hee, Hong, Oak-Kee, Chun, Hyun-Ji, Yoo, Soon-Jib, Baek, Ki-Hyun, Kim, Wook, Kim, Eung Kook, Song, Ki-Ho, Kwon, Hyuk-Sang
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Limiteds 01.01.2013
Hindawi Puplishing Corporation
Hindawi Publishing Corporation
Hindawi Limited
Wiley
Subjects
Abdomen
Adipocytes
Cytokines
Diabetes
Endocrinology
Gastrointestinal surgery
Glucagon
Glucose
Immunoassay
Insulin
Laparoscopy
Peptides
Studies
United States > US
Japan
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Summary:Serum bone morphogenic protein- (BMP-) 4 levels are associated with human adiposity. The aim of this study was to investigate changes in serum levels of BMP-4 and inflammatory cytokines after Roux-en-Y gastric bypass (RYGB). Fifty-seven patients with type 2 diabetes underwent RYGB. Serum levels of BMP-4 and various inflammatory markers, including high-sensitivity C-reactive protein (hsCRP), free fatty acids (FFAs), and plasminogen activator inhibitor- (PAI-) 1, were measured before and 12 months after RYGB. Remission was defined as glycated hemoglobin <6.5% for at least 1 year in the absence of medications. Levels of PAI-1, hsCRP, and FFAs were significantly decreased at 1 year after RYGB. BMP-4 levels were also significantly lower at 1 year after RYGB than at baseline (P=0.024). Of the 57 patients, 40 (70%) had diabetes remission at 1 year after surgery (remission group). Compared with patients in the nonremission group, patients in the remission group had lower PAI-1 levels and smaller visceral fat areas at baseline. There was a difference in the change in the BMP-4 level according to remission status. Our data demonstrate a significant beneficial effect of bariatric surgery on established cardiovascular risk factors and a reduction in chronic nonspecific inflammation after surgery.
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Academic Editor: Ricardo V. García-Mayor
ISSN:1687-8337
1687-8345
DOI:10.1155/2013/681205