Determination of Antibiotic Effect in an In Vitro Pharmacodynamic Model: Comparison with an Established Animal Model of Infection

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Published inAntimicrobial Agents and Chemotherapy Vol. 46; no. 11; pp. 3574 - 3579
Main Authors BONAPACE, Charles R, FRIEDRICH, Lawrence V, BOSSO, John A, WHITE, Roger L
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.11.2002
Subjects
Animals
Anti-Bacterial Agents
Anti-Bacterial Agents - pharmacokinetics
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacillus subtilis - drug effects
Bacterial Infections
Bacterial Infections - drug therapy
Bacterial Infections - microbiology
Biological and medical sciences
Colony Count, Microbial
Experimental Therapeutics
Linear Models
Medical sciences
Mice
Microbial Sensitivity Tests
Models, Biological
Neutropenia - complications
Neutropenia - microbiology
Pharmacology. Drug treatments
Pseudomonas aeruginosa - drug effects
Pseudomonas Infections - drug therapy
Pseudomonas Infections - microbiology
Time Factors
Pseudomonadales
Animal model
Intravenous administration
β-Lactams
Rodentia
Ticarcillin
In vitro
Biological activity
Penicillin derivatives
In vivo
Vertebrata
Antibiotic
Mammalia
Mouse
Minimum inhibitory concentration
Bacteria
Pseudomonadaceae
Pseudomonas aeruginosa
Antibacterial agent
Pharmacokinetics
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
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content type line 23
Corresponding author. Mailing address: Anti-Infective Research Laboratory, Medical University of South Carolina, College of Pharmacy, 280 Calhoun St., P.O. Box 250142, Charleston, SC 29425. Phone: (843) 792-8501. Fax: (843) 792-1712. E-mail: bossoja@musc.edu.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.46.11.3574-3579.2002