Targeting Antigens to Dendritic Cell Receptors for Vaccine Development

Dendritic cells (DCs) are highly specialized antigen presenting cells of the immune system which play a key role in regulating immune responses. Depending on the method of antigen delivery, DCs stimulate immune responses or induce tolerance. As a consequence of the dual function of DCs, DCs are stud...

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Bibliographic Details
Published inJournal of Drug Delivery Vol. 2013; no. 2013; pp. 261 - 282
Main Authors Apostolopoulos, Vasso, Thalhammer, Theresia, Tzakos, Andreas G., Stojanovska, Lily
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Limiteds 01.01.2013
Hindawi Puplishing Corporation
Hindawi Publishing Corporation
Hindawi Limited
Subjects
Antigens
Dendritic cells
Health aspects
Physiological aspects
Review
Vaccines
Greece
Australia
Austria
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Summary:Dendritic cells (DCs) are highly specialized antigen presenting cells of the immune system which play a key role in regulating immune responses. Depending on the method of antigen delivery, DCs stimulate immune responses or induce tolerance. As a consequence of the dual function of DCs, DCs are studied in the context of immunotherapy for both cancer and autoimmune diseases. In vaccine development, a major aim is to induce strong, specific T-cell responses. This is achieved by targeting antigen to cell surface molecules on DCs that efficiently channel the antigen into endocytic compartments for loading onto MHC molecules and stimulation of T-cell responses. The most attractive cell surface receptors, expressed on DCs used as targets for antigen delivery for cancer and other diseases, are discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Academic Editor: Ali Nokhodchi
ISSN:2090-3014
2090-3022
DOI:10.1155/2013/869718