Two types of aggression are differentially related to serotonergic activity and the A779C TPH polymorphism

The authors investigated whether different types of aggression relate to the A779C tryptophan hydroxylase (TPH) polymorphism and to serotonergic activity in volunteers. A factor analysis of the Buss-Durkee Hostility Inventory yielded 2 factors representing Neurotic Hostility (NH) and Aggressive Host...

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Bibliographic Details
Published inBehavioral neuroscience Vol. 119; no. 1; p. 16
Main Authors Hennig, J, Reuter, M, Netter, P, Burk, C, Landt, O
Format Journal Article
LanguageEnglish
Published United States 01.02.2005
Subjects
Adult
Aggression - drug effects
Citalopram - administration & dosage
Citalopram - pharmacology
Genotype
Humans
Hydrocortisone - blood
Male
Polymorphism, Genetic
Psychiatric Status Rating Scales
Serotonin - pharmacology
Serotonin Uptake Inhibitors - administration & dosage
Serotonin Uptake Inhibitors - pharmacology
Tryptophan Hydroxylase - genetics
Tryptophan Hydroxylase - pharmacology
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Summary:The authors investigated whether different types of aggression relate to the A779C tryptophan hydroxylase (TPH) polymorphism and to serotonergic activity in volunteers. A factor analysis of the Buss-Durkee Hostility Inventory yielded 2 factors representing Neurotic Hostility (NH) and Aggressive Hostility (AH). The authors used a neuroendocrine challenge with Citalopram in 48 volunteers and increased cortisol concentrations only in those with high levels of AH. Finally, an association study with 58 volunteers revealed that the A779C TPH polymorphism significantly relates to AH, with the highest aggression levels for the genotype AA and the lowest aggression levels for the genotype CC, but not to NH. Results are discussed with respect to inconsistent findings in the literature, which may be explained by this distinction of types of aggression.
ISSN:0735-7044
DOI:10.1037/0735-7044.119.1.16