Equivalent Steady-State Pharmacokinetics of Lamivudine in Plasma and Lamivudine Triphosphate within Cells following Administration of Lamivudine at 300 Milligrams Once Daily and 150 Milligrams Twice Daily

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Published inAntimicrobial Agents and Chemotherapy Vol. 48; no. 1; pp. 176 - 182
Main Authors Yuen, Geoffrey J., Lou, Yu, Bumgarner, Nancy F., Bishop, Jim P., Smith, Glenn A., Otto, Victoria R., Hoelscher, David D.
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.01.2004
Subjects
Adolescent
Adult
Anti-HIV Agents
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - blood
Anti-HIV Agents - pharmacokinetics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Area Under Curve
Biological and medical sciences
Cross-Over Studies
Female
Human immunodeficiency virus
Humans
Intracellular Space - metabolism
Lamivudine
Lamivudine - administration & dosage
Lamivudine - blood
Lamivudine - pharmacokinetics
Male
Medical sciences
Middle Aged
Monocytes - metabolism
Pharmacology
Pharmacology. Drug treatments
Therapeutic Equivalency
Biological fluid
RNA-directed DNA polymerase
Enzyme
Transferases
Enzyme inhibitor
Lamivudine
Blood plasma
Nucleotidyltransferases
Dideoxynucleoside
Reverse transcriptase inhibitor
Antiviral
Nucleosidic analog
Pharmacokinetics
Pyrimidine nucleoside
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
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Corresponding author. Mailing address: Clinical Pharmacology and Discovery Medicine, Full Development, GlaxoSmithKline, 5 Moore Dr., Research Triangle Park, NC 27709. Phone: (919) 483-5676. Fax: (919) 483-6380. E-mail: gjy25826@glaxowellcome.com.
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.48.1.176-182.2004