Bactericidal Activity of Multiple Combinations of Tigecycline and Colistin against NDM-1-Producing Enterobacteriaceae

• Published in: Antimicrobial Agents and Chemotherapy Vol. 56; no. 6; pp. 3441 - 3443
• Main Authors: Albur, Mahableshwar, Noel, Alan, Bowker, Karen, MacGowan, Alasdair
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.06.2012
• Subjects: Antagonism; Anti-Bacterial Agents; Anti-Bacterial Agents - pharmacology; antibacterial properties; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacteria; Bactericidal activity; beta-Lactamases; beta-Lactamases - genetics; beta-Lactamases - metabolism; Biological and medical sciences; blood serum; Clinical Therapeutics; Colistin; Colistin - pharmacology; Colistin sulfate; Drug Antagonism; Drug Resistance, Multiple, Bacterial; Drugs; Enterobacteriaceae; Enterobacteriaceae - drug effects; Enterobacteriaceae - enzymology; Medical sciences; microbial growth; Microbial Sensitivity Tests; Minocycline; Minocycline - analogs & derivatives; Minocycline - pharmacology; Pharmacology. Drug treatments; regrowth; tigecycline; Glycylcycline derivatives; Antibiotic; Multiple; Colistin; Cyclic peptides; Polypeptide; Bacteria; Antibacterial agent; Tigecycline; Biological activity; Enterobacteriaceae

The interaction between colistin and tigecycline against eight well-characterized NDM-1-producing Enterobacteriaceae strains was studied. Time-kill methodology was employed using a 4-by-4 exposure matrix with pharmacokinetically achievable free drug peak, trough, and average 24-h serum concentration...