Bactericidal Activity of Multiple Combinations of Tigecycline and Colistin against NDM-1-Producing Enterobacteriaceae

• Published in: Antimicrobial Agents and Chemotherapy Vol. 56; no. 6; pp. 3441 - 3443
• Main Authors: Albur, Mahableshwar, Noel, Alan, Bowker, Karen, MacGowan, Alasdair
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.06.2012
• Subjects: Antagonism; Anti-Bacterial Agents; Anti-Bacterial Agents - pharmacology; antibacterial properties; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacteria; Bactericidal activity; beta-Lactamases; beta-Lactamases - genetics; beta-Lactamases - metabolism; Biological and medical sciences; blood serum; Clinical Therapeutics; Colistin; Colistin - pharmacology; Colistin sulfate; Drug Antagonism; Drug Resistance, Multiple, Bacterial; Drugs; Enterobacteriaceae; Enterobacteriaceae - drug effects; Enterobacteriaceae - enzymology; Medical sciences; microbial growth; Microbial Sensitivity Tests; Minocycline; Minocycline - analogs & derivatives; Minocycline - pharmacology; Pharmacology. Drug treatments; regrowth; tigecycline; Glycylcycline derivatives; Antibiotic; Multiple; Colistin; Cyclic peptides; Polypeptide; Bacteria; Antibacterial agent; Tigecycline; Biological activity; Enterobacteriaceae
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.05682-11

The interaction between colistin and tigecycline against eight well-characterized NDM-1-producing Enterobacteriaceae strains was studied. Time-kill methodology was employed using a 4-by-4 exposure matrix with pharmacokinetically achievable free drug peak, trough, and average 24-h serum concentrations. Colistin sulfate and methanesulfonate alone showed good early bactericidal activity, often with subsequent regrowth. Tigecycline alone had poor activity. Addition of tigecycline to colistin does not produce increased bacterial killing; instead, it may cause antagonism at lower concentrations.