Conservation of Amino Acids in Human Rhinovirus 3C Protease Correlates with Broad-Spectrum Antiviral Activity of Rupintrivir, a Novel Human Rhinovirus 3C Protease Inhibitor

• Published in: Antimicrobial Agents and Chemotherapy Vol. 49; no. 2; pp. 619 - 626
• Main Authors: BINFORD, S. L, MALDONADO, F, BROTHERS, M. A, WEADY, P. T, ZALMAN, L. S, MEADOR, J. W, MATTHEWS, D. A, PATICK, A. K
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.02.2005
• Subjects: 3C Viral Proteases; Amino Acids; Amino Acids - metabolism; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Antiviral Agents - pharmacology; Biological and medical sciences; Conserved Sequence; Cysteine Endopeptidases; Cysteine Endopeptidases - drug effects; Cysteine Endopeptidases - genetics; Cysteine Endopeptidases - metabolism; HeLa Cells; Hepatitis E virus; Human rhinovirus; Humans; Isoxazoles; Isoxazoles - pharmacology; Medical sciences; Molecular Sequence Data; Pharmacology. Drug treatments; Phenylalanine - analogs & derivatives; Picornavirus; Protease Inhibitors; Protease Inhibitors - pharmacology; Pyrrolidinones; Pyrrolidinones - pharmacology; Reverse Transcriptase Polymerase Chain Reaction; Rhinovirus; Rhinovirus - enzymology; Rhinovirus - genetics; RNA, Viral - genetics; Valine - analogs & derivatives; Viral Proteins; Viral Proteins - drug effects; Viral Proteins - genetics; Viral Proteins - metabolism; Peptidases; Rupintrivir; Enzyme; Cysteine endopeptidases; Aminoacid; Conservation; Hydrolases; Antiviral; Inhibitor; Activity spectrum; Picornain 3C
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.49.2.619-626.2005

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