Synthesis of Natural Products Using Engineered Plants and Microorganisms

• Format: eBook
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2024
• Subjects: 4-diaminobutane; ABC transporter family; active compounds; anti-acute lung injury; antioxidant stress; applied research; Ardisiae Japonicae Herba; Artemisia annua; artemisinin; bile acid metabolism; bioactivities; biological nano selenium; biologically active compounds; Biology, life sciences; biosynthesis; biosynthetic gene clusters; biotransformation; catalytic mechanism; Citrus reticulata ‘chachi’; cofactor; cytotoxic activity; downstream processing; endophytic bacteria; Epimedium; epithelization; ergostane steroids; essential oils; excision wound; extraction and identification methods; extraction methods; fed-batch process; fermentation; flavonoid; flavonoids; Ganoderma luteomarginatum; genetic engineering; ginsenoside CK; ginsenoside PPD; ginsenoside Rb1; gut microbiota; hyperlipidemia; Klebsiella aerogenes; L-cysteine; lanostane triterpenoids; lignin linkages; lignocellulose; Lycium ruthenicum Murray; Mathematics and Science; metabolic engineering; metabolome; n/a; NADPH; nutritional composition; organic selenium; pharmacological activities; PLP; Reference, Information and Interdisciplinary subjects; Research and information: general; synanthropic herbaceous plants; synthetic biology; transcription factor; transcriptome; UPLC–Orbitrap Fusion–MS; wound healing; Zoology and animal sciences
• ISBN: 3725826064; 9783725826063; 9783725826056; 3725826056
• DOI: 10.3390/books978-3-7258-2605-6

Plants and microorganisms, particularly medicinal herbs, harbor a diverse array of natural products. Many of these are bioactive molecules with potential applications in pharmaceuticals and healthcare. However, the concentrations of these bioactive compounds in plants or microorganisms are usually low. The advancement of omics technologies and synthetic biology has opened up new possibilities for producing these bioactive molecules through the metabolic engineering of plants and microorganisms. Especially substances like artemisinin, rare ginsenosides, and several other natural products have already been successfully manufactured on a large scale. This reprint aims to provide an overview of the current state-of-the-art synthetic biology and engineering biology technologies used in plants and microorganisms for the biosynthesis and scalable production of natural products.