The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation 2.0

• Format: eBook
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2024
• Subjects: acute respiratory distress syndrome; adaptive immunity; adipocyte; adipose tissue; ARDS; arrhythmia; atherosclerosis; behavior; Biology, life sciences; blood–brain barrier; brain; C5a; cardiomyocytes; cathelicidin anti-microbial peptide; CCL20; CCL4; CCR2; CD163; CD68; cfDNA; co-infection; cognition; complement; COVID-19; cytokine storm; cytokines; dimerization; experimental autoimmune encephalomyelitis; galectin-3; HBV; HCV; heart dysfunction; heterodimerization; HIV-1; homodimerization; host genetics; immune-to-brain communication; immunity; inflammation; innate immunity; lethal COVID-19; ligands; lipid mediators; lipopolysaccharide; lung disease; lung–brain axis; M1 macrophages; M2 macrophages; macrophage shift; Mathematics and Science; MYD88; myeloid differentiation factor-2 (MD-2); n/a; neurodegeneration; neurogenesis; neuroinflammation; neutrophils; NF-kappa B; NOD2; omega-3 fatty acids; Omicron; Reference, Information and Interdisciplinary subjects; Research and information: general; resolvin E1 receptors; SARS-CoV-2; sepsis; spike protein; statin; synergy; TLR; TLR (toll-like receptor) 9; TLR agonist; TLR-4; TLR4/MD-2; TLR7; TLRs; TNFα; Toll-like receptor; toll-like receptor (TLR); Toll-like receptor 2; Toll-like receptors; type I IFN
• ISBN: 9783725823437; 3725823448; 9783725823444; 372582343X
• DOI: 10.3390/books978-3-7258-2343-7

This Special Issue 2.0 continues the conceptional line started in the previous Special Issue, focusing on the involvement of Toll-like receptors (TLRs) and their related signaling pathways in viral infection and inflammation, and emphasizing the therapeutic potential of TLR system modulation for the treatment of acute viral infections and their long-term sequelae and to provide potential targets for treating chronic viral and inflammatory diseases. This Special Issue provides an excellent collection of contemporary reviews and research articles covering a broad variety of topics, ranging from the protective activity of TLRs in viral infections to detrimental disturbances of the host immune system. The most intriguing theme discussed in this second Special Issue is the intercorrelation between acute viral infections and triggered delayed effects, including neuroinflammatory and neurodegenerative long-term sequelae. Notably, new data increasingly show that neurological pathways, such as neurogenesis, neuroinflammation, and cognitive and behavioural aspects, may be influenced by innate, TLR-mediated pathways. In this context, the connection between infection-triggered acute disbalance in TLR activation and resulting neurological sequelae following bacterial (sepsis) or viral infections, including long COVID-associated neurological sequelae, may provide new targets for future treatment options.