Demystifying heparan sulfate-protein interactions

Numerous proteins, including cytokines and chemokines, enzymes and enzyme inhibitors, extracellular matrix proteins, and membrane receptors, bind heparin. Although they are traditionally classified as heparin-binding proteins, under normal physiological conditions these proteins actually interact wi...

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Bibliographic Details
Published inAnnual review of biochemistry Vol. 83; p. 129
Main Authors Xu, Ding, Esko, Jeffrey D
Format Journal Article
LanguageEnglish
Published United States 01.01.2014
Subjects
Animals
Binding Sites
Carbohydrates - chemistry
Extracellular Matrix - metabolism
Glucuronidase - chemistry
Heparitin Sulfate - chemistry
Humans
Hydrogen Bonding
Ligands
Macromolecular Substances
Oligosaccharides - chemistry
Protein Binding
Protein Interaction Mapping
Protein Structure, Secondary
Proteins - chemistry
Proteoglycans - chemistry
glycan–protein interaction
oligomerization
glycosaminoglycan
heparin-binding protein
heparan sulfate–binding domain
proteoglycan
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Summary:Numerous proteins, including cytokines and chemokines, enzymes and enzyme inhibitors, extracellular matrix proteins, and membrane receptors, bind heparin. Although they are traditionally classified as heparin-binding proteins, under normal physiological conditions these proteins actually interact with the heparan sulfate chains of one or more membrane or extracellular proteoglycans. Thus, they are more appropriately classified as heparan sulfate-binding proteins (HSBPs). This review provides an overview of the various modes of interaction between heparan sulfate and HSBPs, emphasizing biochemical and structural insights that improve our understanding of the many biological functions of heparan sulfate.
ISSN:1545-4509
DOI:10.1146/annurev-biochem-060713-035314