Effects of Probenecid and Cimetidine on Renal Disposition of Ofloxacin in Rats

• Published in: Antimicrobial Agents and Chemotherapy Vol. 42; no. 2; pp. 456 - 458
• Main Authors: FOOTE, E. F, HALSTENSON, C. E
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.02.1998
• Series: Note
• Subjects: Animals; Anti-Infective Agents - pharmacokinetics; Anti-Infective Agents - urine; Anti-Ulcer Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Cimetidine - pharmacology; Drug Interactions; Kidney - drug effects; Kidney - physiology; Male; Medical sciences; Metabolic Clearance Rate; Ofloxacin - pharmacokinetics; Ofloxacin - urine; Pharmacology; Pharmacology. Drug treatments; Probenecid - pharmacology; Rats; Rats, Sprague-Dawley; Renal Agents - pharmacology; Drug combination; Intravenous administration; Rat; Biological transport; Rodentia; Cimetidine; Ofloxacin; Antihistaminic; Uricosuric agent; Blood plasma; Vertebrata; Antibiotic; Fluoroquinolone derivatives; Renal tubule; Mammalia; Urinary system; Animal; Antisecretory agent; Inulin; Drug interaction; Antibacterial agent; Pharmacokinetics; Quinolone derivatives; Probenecid
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.42.2.456

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