Selection of an oral prodrug (BRL 42810; famciclovir) for the antiherpesvirus agent BRL 39123 [9-(4-hydroxy-3-hydroxymethylbut-l-yl)guanine; penciclovir]

• Published in: Antimicrobial Agents and Chemotherapy Vol. 33; no. 10; pp. 1765 - 1773
• Main Authors: VERE HODGE, R. A, SUTTON, D, BOYD, M. R, HARNDEN, M. R, JARVEST, R. L
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.10.1989
• Subjects: 2-Aminopurine; 2-Aminopurine - analogs & derivatives; 2-Aminopurine - pharmacokinetics; Acyclovir; Acyclovir - analogs & derivatives; Acyclovir - pharmacokinetics; Adenine; Adenine - analogs & derivatives; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Antiviral Agents - pharmacokinetics; Bile - metabolism; Biological and medical sciences; Biological Availability; Chromatography, High Pressure Liquid; Duodenum - metabolism; Famciclovir; Humans; In Vitro Techniques; Intestinal Mucosa - metabolism; Liver - metabolism; Male; Medical sciences; Pharmacology. Drug treatments; Prodrugs; Rats; Research Article; Tissue Distribution; Human; Stability; Rat; Herpesviridae; Rodentia; Oral administration; Bioavailability; Prodrug; Metabolism; In vitro; Optimization; Virus; In vivo; Vertebrata; Mammalia; Animal; Antiviral; Chemical properties; Pharmacokinetics
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.33.10.1765

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