Neurotoxic Mode of Action of Artemisinin

• Published in: Antimicrobial Agents and Chemotherapy Vol. 46; no. 3; pp. 821 - 827
• Main Authors: SCHMUCK, Gabriele, ROEHRDANZ, Elke, HAYNES, Richard K, KAHL, Regine
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.03.2002
• Subjects: Adenosine Triphosphate - metabolism; Animals; Antimalarials; Antimalarials - toxicity; artemisinin; Artemisinins; Artemsisia Annua; Biological and medical sciences; Cell Survival; Cells, Cultured; Cytoskeleton - drug effects; Cytoskeleton - metabolism; Drug toxicity and drugs side effects treatment; Energy Metabolism - drug effects; Enzyme-Linked Immunosorbent Assay; Lipid Peroxidation - drug effects; Mechanisms of Action: Physiological Effects; Medical sciences; Membrane Potentials; Mitochondria - drug effects; Mitochondria - physiology; Neurofilament Proteins - metabolism; Neurons - drug effects; Neurons - metabolism; Neurotoxicity Syndromes; Neurotoxicity Syndromes - pathology; Neurotoxins; Neurotoxins - toxicity; Oxidative Stress - drug effects; Pharmacology. Drug treatments; Rats; Reactive Oxygen Species - metabolism; RNA - biosynthesis; RNA - genetics; Sesquiterpenes; Sesquiterpenes - toxicity; Toxicity: nervous system and muscle; Glutathione peroxidase; Antimalarial; Oxidative stress; Enzyme; Toxicity; Artemisinin; Lipids; Superoxide dismutase; Gene expression; Cerebral disorder; Neuron; Peroxidases; Parasiticid; Central nervous system disease; Cytoskeleton; Oxidoreductases; Mechanism of action; Peroxidation
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.46.3.821-827.2002

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