Importance of Multidrug Efflux Pumps in the Antimicrobial Resistance Property of Clinical Multidrug-Resistant Isolates of Neisseria gonorrhoeae
The contribution of drug efflux pumps in clinical isolates of Neisseria gonorrhoeae that express extensively drug-resistant or multidrug-resistant phenotypes has heretofore not been examined. Accordingly, we assessed the effect on antimicrobial resistance of loss of the three gonococcal efflux pumps...
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| Published in | Antimicrobial agents and chemotherapy Vol. 58; no. 6; pp. 3556 - 3559 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Washington, DC
American Society for Microbiology
01.06.2014
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The contribution of drug efflux pumps in clinical isolates of
Neisseria gonorrhoeae
that express extensively drug-resistant or multidrug-resistant phenotypes has heretofore not been examined. Accordingly, we assessed the effect on antimicrobial resistance of loss of the three gonococcal efflux pumps associated with a known capacity to export antimicrobials (MtrC-MtrD-MtrE, MacA-MacB, and NorM) in such clinical isolates. We report that the MIC of several antimicrobials, including seven previously and currently recommended for treatment was significantly impacted. |
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| AbstractList | The contribution of drug efflux pumps in clinical isolates of Neisseria gonorrhoeae that express extensively drug-resistant or multidrug-resistant phenotypes has heretofore not been examined. Accordingly, we assessed the effect on antimicrobial resistance of loss of the three gonococcal efflux pumps associated with a known capacity to export antimicrobials (MtrC-MtrD-MtrE, MacA-MacB, and NorM) in such clinical isolates. We report that the MIC of several antimicrobials, including seven previously and currently recommended for treatment was significantly impacted. The contribution of drug efflux pumps in clinical isolates of Neisseria gonorrhoeae that express extensively drug-resistant or multidrug-resistant phenotypes has heretofore not been examined. Accordingly, we assessed the effect on antimicrobial resistance of loss of the three gonococcal efflux pumps associated with a known capacity to export antimicrobials (MtrC-MtrD-MtrE, MacA-MacB, and NorM) in such clinical isolates. We report that the MIC of several antimicrobials, including seven previously and currently recommended for treatment was significantly impacted.The contribution of drug efflux pumps in clinical isolates of Neisseria gonorrhoeae that express extensively drug-resistant or multidrug-resistant phenotypes has heretofore not been examined. Accordingly, we assessed the effect on antimicrobial resistance of loss of the three gonococcal efflux pumps associated with a known capacity to export antimicrobials (MtrC-MtrD-MtrE, MacA-MacB, and NorM) in such clinical isolates. We report that the MIC of several antimicrobials, including seven previously and currently recommended for treatment was significantly impacted. The contribution of drug efflux pumps in clinical isolates of Neisseria gonorrhoeae that express extensively drug-resistant or multidrug-resistant phenotypes has heretofore not been examined. Accordingly, we assessed the effect on antimicrobial resistance of loss of the three gonococcal efflux pumps associated with a known capacity to export antimicrobials (MtrC-MtrD-MtrE, MacA-MacB, and NorM) in such clinical isolates. We report that the MIC of several antimicrobials, including seven previously and currently recommended for treatment was significantly impacted. |
| Author | Golparian, Daniel Ohnishi, Makoto Unemo, Magnus Shafer, William M. |
| Author_xml | – sequence: 1 givenname: Daniel surname: Golparian fullname: Golparian, Daniel organization: WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections (STIs), National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden – sequence: 2 givenname: William M. surname: Shafer fullname: Shafer, William M. organization: Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA, Laboratories of Bacterial Pathogenesis, Veterans Affairs Medical Center, Decatur, Georgia, USA – sequence: 3 givenname: Makoto surname: Ohnishi fullname: Ohnishi, Makoto organization: National Institute of Infectious Diseases, Tokyo, Japan – sequence: 4 givenname: Magnus surname: Unemo fullname: Unemo, Magnus organization: WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections (STIs), National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden |
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| Copyright | 2015 INIST-CNRS Copyright © 2014, American Society for Microbiology. All Rights Reserved. Copyright © 2014, American Society for Microbiology. All Rights Reserved. 2014 American Society for Microbiology |
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| Keywords | Human Drug susceptibility test Neisseriaceae Antimicrobial agent Infection Sexually transmitted disease Gonococcal infection Neisseria gonorrhoeae Membrane pump Membrane transport Multiple resistance Bacteriosis Bacteria Micrococcales Clinical isolate |
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| Snippet | The contribution of drug efflux pumps in clinical isolates of
Neisseria gonorrhoeae
that express extensively drug-resistant or multidrug-resistant phenotypes... The contribution of drug efflux pumps in clinical isolates of Neisseria gonorrhoeae that express extensively drug-resistant or multidrug-resistant phenotypes... |
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| SubjectTerms | Anti-Bacterial Agents Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial diseases Bacterial diseases of the genital system Bacterial Proteins - genetics Bacterial Proteins - metabolism Biological and medical sciences Drug Resistance, Multiple, Bacterial - genetics Epidemiology. Vaccinations General aspects Genes, MDR Genes, MDR - physiology Gonorrhea Gonorrhea - microbiology Human bacterial diseases Humans Infectious diseases Mechanisms of Resistance Medical sciences Membrane Transport Proteins Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Microbial Sensitivity Tests Mutation Neisseria gonorrhoeae Neisseria gonorrhoeae - drug effects Neisseria gonorrhoeae - genetics Pharmacology. Drug treatments |
| Title | Importance of Multidrug Efflux Pumps in the Antimicrobial Resistance Property of Clinical Multidrug-Resistant Isolates of Neisseria gonorrhoeae |
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