CS-8958, a Prodrug of the Novel Neuraminidase Inhibitor R-125489, Demonstrates a Favorable Long-Retention Profile in the Mouse Respiratory Tract

• Published in: Antimicrobial Agents and Chemotherapy Vol. 53; no. 11; pp. 4845 - 4851
• Main Authors: KOYAMA, Kumiko, TAKAHASHI, Makoto, OITATE, Masataka, NAKAI, Naoko, TAKAKUSA, Hideo, MIURA, Shin-Ichi, OKAZAKI, Osamu
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.11.2009; American Society for Microbiology (ASM)
• Subjects: Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Antiviral Agents - pharmacokinetics; Autoradiography; Biological and medical sciences; Enzyme Inhibitors; Enzyme Inhibitors - pharmacokinetics; Esterases - antagonists & inhibitors; Female; Lung; Lung - metabolism; Medical sciences; Mice; Mice, Inbred BALB C; Neuraminidase; Neuraminidase - antagonists & inhibitors; Orthomyxoviridae; Orthomyxoviridae - drug effects; Pharmacology. Drug treatments; Prodrugs; Prodrugs - pharmacokinetics; Trachea; Trachea - metabolism; Zanamivir; Zanamivir - analogs & derivatives; Zanamivir - pharmacokinetics; Respiratory tract; Vertebrata; Mammalia; Neuraminidase inhibitor; Mouse; Animal; Rodentia; Prodrug; Profile
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.00731-09

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