Executive Dysfunction in MCI : Subtype or Early Symptom

Mild cognitive impairment (MCI) may take several forms, and amnestic MCI (aMCI) has been recognized as an early stage of Alzheimer’s Disease (AD). Impairment in executive functions including attention (eMCI) may be indicative of several neurodegenerative conditions. Executive impairment is frequentl...

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Bibliographic Details
Published inInternational journal of alzheimer's disease Vol. 2012; no. 2012; pp. 1 - 8
Main Authors Reinvang, Ivar, Grambaite, Ramune, Espeseth, Thomas
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Puplishing Corporation 2012
Hindawi Publishing Corporation
Hindawi Limited
Subjects
Aging
Alzheimer's disease
Cognition & reasoning
Review
Studies
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Summary:Mild cognitive impairment (MCI) may take several forms, and amnestic MCI (aMCI) has been recognized as an early stage of Alzheimer’s Disease (AD). Impairment in executive functions including attention (eMCI) may be indicative of several neurodegenerative conditions. Executive impairment is frequently found in aMCI, it is significant for prognosis, and patients with eMCI may go on to develop AD. Recent studies have found changes in white matter integrity in patients with eMCI to be more sensitive than measures of cortical atrophy. Studies of genetic high-risk groups using sensitive cognitive neuroscience paradigms indicate that changes in executive function may be a cognitive marker useful for tracking development in an AD pathophysiological process.
Bibliography:ObjectType-Article-1
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Academic Editor: Štefan Krajcík
ISSN:2090-8024
2090-0252
DOI:10.1155/2012/936272