4′-Ethynyl Nucleoside Analogs: Potent Inhibitors of Multidrug-Resistant Human Immunodeficiency Virus Variants In Vitro

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Published inAntimicrobial Agents and Chemotherapy Vol. 45; no. 5; pp. 1539 - 1546
Main Authors KODAMA, Ei-Ichi, KOHGO, Satoru, KITANO, Kenji, MACHIDA, Haruhiko, GATANAGA, Hiroyuki, SHIGETA, Shiro, MATSUOKA, Masao, OHRUI, Hiroshi, MITSUYA, Hiroaki
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.05.2001
Subjects
4-Ethynyl nucleosides
Anti-HIV Agents
Anti-HIV Agents - antagonists & inhibitors
Anti-HIV Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral Agents
Biological and medical sciences
Deoxyribonucleosides
Deoxyribonucleosides - antagonists & inhibitors
Deoxyribonucleosides - pharmacology
Drug Interactions
Drug Resistance, Multiple - physiology
Drug Stability
HIV Infections - virology
HIV-1
HIV-1 - drug effects
HIV-1 - isolation & purification
HIV-2 - drug effects
Human immunodeficiency virus 1
Humans
Medical sciences
Microbial Sensitivity Tests
nucleoside analogues
nucleosides
Pharmacology. Drug treatments
RNA-directed DNA polymerase
Enzyme
Transferases
Retroviridae
Enzyme inhibitor
Lentivirus
In vitro
Biological activity
Virus
Nucleotidyltransferases
Analog
Multiple resistance
Antiviral
Nucleoside
Replication
Human immunodeficiency virus
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
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Corresponding author. Mailing address: Medicine Branch, Building 10, Room 5A11, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892. Phone: (301) 402-3631. Fax: (301) 402-0709. E-mail: hmitsuya@helix.nih.gov.
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.45.5.1539-1546.2001