Immune targets to stop future SARS-CoV-2 variants

The emergence of SARS-CoV-2 had a major impact across the world. It is true that the collaboration of scientists from all over the world resulted in a rapid response against COVID-19, mainly with the development of vaccines against the disease. However, many viral genetic variants that threaten vacc...

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Published inMicrobiology spectrum Vol. 11; no. 6; p. e0289223
Main Authors Silva Souza, Milena, Pires Farias, Jéssica, Barros Luiz, Wilson, Birbrair, Alexander, Durães-Carvalho, Ricardo, de Souza Ferreira, Luís Carlos, Amorim, Jaime Henrique
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 12.12.2023
Subjects
conservation
COVID-19
epitope
Humans
immune targets
Physicians
Research Article
SARS-CoV-2
SARS-CoV-2 - genetics
Vaccines
variant of concern
Virology
variant of concern
SARS-CoV-2
conservation
immune targets
epitope
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Summary:The emergence of SARS-CoV-2 had a major impact across the world. It is true that the collaboration of scientists from all over the world resulted in a rapid response against COVID-19, mainly with the development of vaccines against the disease. However, many viral genetic variants that threaten vaccines have emerged. Our study reveals highly conserved antigenic regions in the vaccines have emerged. Our study reveals highly conserved antigenic regions in the spike protein in all variants of concern (Alpha, Beta, Gamma, Delta, and Omicron) as well as in the wild-type virus. Such immune targets can be used to fight future SARS-CoV-2 variants.
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The authors declare no conflict of interest.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.02892-23