Validation of IMP Dehydrogenase Inhibitors in a Mouse Model of Cryptosporidiosis

• Published in: Antimicrobial Agents and Chemotherapy Vol. 58; no. 3; pp. 1603 - 1614
• Main Authors: SURESH KUMAR GORLA, MCNAIR, Nina N, HEDSTROM, Lizbeth, GUANGYI YANG, SONG GAO, MING HU, JALA, Venkatakrishna R, HARIBABU, Bodduluri, STRIEPEN, Boris, CUNY, Gregory D, MEAD, Jan R
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.03.2014
• Subjects: Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Caco-2 Cells - parasitology; Coccidiostats; Coccidiostats - therapeutic use; Cryptosporidiosis; Cryptosporidiosis - drug therapy; Cryptosporidium; Cryptosporidium parvum; Cryptosporidium parvum - drug effects; Disease Models, Animal; Drug Discovery - methods; Experimental Therapeutics; Human protozoal diseases; Humans; IMP Dehydrogenase; IMP Dehydrogenase - antagonists & inhibitors; Infectious diseases; Interleukin-12 - genetics; Medical sciences; Mice; Mice, Inbred C57BL - parasitology; Mice, Knockout - parasitology; Parasitic diseases; Pharmacology. Drug treatments; Protozoal diseases; Validation; Animal model; Protozoal disease; Enzyme; Rodentia; IMP dehydrogenase; Parasitosis; Infection; Cryptosporidiosis; Vertebrata; Mammalia; Mouse; Inhibitor; Oxidoreductases
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.02075-13

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